Lung Health Study and Related Publications

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Lung Health Study and Related Publications

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  1. Owens GR. Lung Health Study: Assessing the impact of early interventon. Monograph: Chronic Bronchitis: Time to Act. Strategies for Prevention and Intervention from the proceedings of the Boehringer Ingelheim Ireland Symposium, Killarney, Ireland, July 1988.

  2. Anthonisen NR. Editorial: Lung Health Study. Am Rev Respir Dis 199, 140:871-872.

  3. Connett, JE, Lee WW. Estimation of the coefficient of variation from laboratory analysis of split specimens for quality control in clinical trials. Controlled Clinical Trials 1990, 11:24-36.

  4. Owens GR. Pulmonary function tests as guides in the differential phyiologic comparisons of obstructive pulmonary diseases. J Respir Dis 1990, II(6):S23-S29.

  5. Enright PL, Johnson LR, Connett JE, Voelker H, Buist AS. Spirometry in the Lung Health Study: I. Methods and quality control. Am Rev Respir Dis 1991, 143:1215-1233.

  6. Hurd SS. Editorial: Lung Health Study: Pulmonary function testing. Am Rev Respir Dis 1991, 143:1211.

  7. Crapo RO. Editorial: Spirometry: Quality control and reproducibility criteria. Am Rev Respir Dis 1991, 143:1212-1213.

  8. Tashkin DP, Rand C, Nides M, Simmons M. Wise R, Coulson AH, Li V, Gon H. A nebulizer chronolog to monitor compliance with inhaler use. Am J Med 1991, 91(4A):33S-36S.

  9. Owens GR. Public screening for lung disease: Experience with the NIH Lung Health Study. American Journal of Medicine 1991, 91(suppl 4A):37S-40S.

  10. Tashkin DP, Altose MD, Bleecker ER, Connett JE, Kanner RE, Lee WW, Wise R, for the Lung Health Study Research Group. The Lung Health Study: Airway responsiveness to inhaled methacholine in smokers with mild to moderate airflow limitation. Am Rev Respir Dis 1992, 145:301-310.

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  11. Rand CS, Wise RA, Nides M, Simmons MS, Bleecker ER, Kusek JW, Li VC, and Tashkin DP. Metered dose inhaler adherence in a clinical trial. Am Rev Respir Dis 1992, 146:1559-1564.

  12. Connett JE, Kusek JW, Bailey WC, O'Hara P, Wu M, for the Lung Health Study Research Group. Design of the Lung Health Study: A Randomized Clinical Trial of Early Intervention for Chronic Obstructive Pulmonary Disease. Controlled Clin Trials 1993, 14(2S):3-19.

  13. Durkin DA, Kjelsberg MO, Buist AS, Connett JE, Owens GR, and Recruitment Directors of the Lung Health Study for the Lung Health Study Research Group. Recruitment of participants in the Lung Health Study, I: Description of Methods. Controlled Clin Trials 1993, 14(2S):20-37.

  14. Connett JE, Bjornson Benson WM, Daniels K, for the Lung Health StudyResearch Group. Recruitment of participants in the Lung Health Study, II: Assessment of recruiting strategies. Controlled Clin Trials 1993, 14(2S):38-51.

  15. Bjornson Benson WM, Stibolt TB, Manske KA, Zavela KJ, Youtsey DJ and Buist AS. Monitoring recruitment effectiveness and cost in a clinical trial. Controlled Clin Trials 1993, 14(2S):52-67.

  16. Rudick C, Anthonisen NR and Manfreda J. Recruiting healthy participants for a large clinical trial. Controlled Clin Trials 1993, 14(2S):68-79.

  17. O'Hara P, Grill J, Rigdon MA, Connett JE, Lauger GG, Johnston JJ, for the Lung Health Study Research Group. Design and results of the initial intervention program for the Lung Health Study. Prev Med 1993, 22:304-315.

  18. Buist AS, Connett JE, Miller RD, Kanner RE, Owens GR, Voelker HT for the Lung Health Study Research Group. Chronic Obstructive Pulmonary Disease Early Intervention Trial (Lung Health Study): Baseline characteristics of randomized participants. Chest 1993, 103(6):1863-1872.

  19. Bjornson Benson WM, Nides MA, Dolce JJ, Rand CS, Lindgren PG, O'Hara P, Buist AS, for the Lung Health Study Research Group. Nicotine gum use in the first year of the Lung Health Study. Addictive Behaviors 1993, 18:491-502.

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  20. Nides MA, Tashkin DP, Simmons MS, Wise RA, Li VC, Rand CS. Improving inhaler adherence in a clinical trial through the use of the nebulizer chronolog. Chest 1993, 104:501-507.

  21. Murray RP, Connett JE, Lauger GG, Voelker HT, for the Lung Health Study Research Group. Error in smoking measures: Effects of intervention on relations of cotinine and carbon monoxide to self reported smoking. Am J Public Health 1993, 83(9):1251-1257.

  22. Istvan JA, Nides MA, Buist AS, Greene P, Voelker H, for the Lung Health Study Research Group. Salivary cotinine, frequency of cigarette smoking, and body mass index: Findings at baseline in the Lung Health Study. Am J Epidemiology 1994, 139(6):628-636.

  23. Wu MC, Lan KKG, Connett JE. Use of surrogate information time for monitoring the effect of treatment on the change in a response variable in clinical trials. Statistics in Medicine 1994, 13:945-953.

  24. Nides M, Rand C, Dolce J, Murray R, O'Hara P, Voelker H, and Connett J. Weight gain as a function of smoking cessation and 2 mg nicotine gum use among middle aged smokers with mild lung impairment in the first 2 years of the Lung Health Study. Health Psychology 1994, 13(4):354-361.

  25. Kanner RE, Connett JE, Altose MD, Buist AS, Lee WW, Tashkin DP, and Wise RA for the Lung Health Study Research Group. Gender difference in airway hyperresponsiveness in smokers with mild COPD. Am J Respir Crit Care Med 1994, 150:956-961.

  26. Johnson LR, Enright PL, Voelker HT, Tashkin DP. Volume spirometers need automated internal temperature sensors. Am J Respir Crit Care Med 1994, 150:1575-1580.

  27. Anthonisen NR, Connett JE, Kiley JP et al. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1: The Lung Health Study. JAMA 1994, 272(19):1497-1505.

  28. Gross NJ. Editorial: The Lung Health Study: Disappointment and Triumph. JAMA 1994, 272(19):1539-1541.

  29. Istvan JA, Buist AS, Hess DL, Voelker H. Relationship of smoking cessation and nicotine gum use to salivary androstenedione and testosterone in middle aged men. Metabolism 1995, 44(1):90-95.

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  30. Murray RP, Istvan JA, Voelker HT, Rigdon MA, Wallace MD. Level of involvement with alcohol and success at smoking cessation in the Lung Health Study. J Studies on Alcohol 1995, 56:74-82.

  31. Bjornson W, Rand C, Connett JE, Lindgren P, Nides M, Pope F, Buist A, Hoppe Ryan C, O'Hara P, for the Lung Health Study Research Group. Gender differences in smoking cessation after 3 years in the Lung Health Study. Am J Public Health 1995, 85:223-230.

  32. Enright PL, Connett JE, Kanner RE, Johnson LR, Lee WW for the Lung Health Study Group. Spirometry in the Lung Health Study: II. Determinants of short term intraindividual variability. Am J Respir Crit Care Med 1995, 151:406-411.

  33. Tashkin DP, Altose MD, Connett JE, Kanner RE, Lee WW, Wise R and the Lung Health Study Research Group. Airway hyperresponsiveness in "irreversible" chronic obstructive pulmonary disease. In: Spector SL, editor. Provocation Testing in Clinical Practice. New York: Marcel Dekker, Inc., 1995:575-598.

  34. Nides MA, Rakos RF, Gonzales D, Murray RP, Tashkin DP, Bjornson Benson WM, Lindgren P, Connett JE for the Lung Health Study Research Group. Predictors of initial smoking cessation and relapse through the first two years of the Lung Health Study. J. Consulting and Clinical Psychology 1995, 63:60-69.

  35. Wise RA, Connett J, Kurnow K, Grill J, Johnson L, Kanner R, Enright P and the Lung Health Study Group. Selection of spirometric measurements in a clinical trial, the Lung Health Study. Am J Respir Crit Care Med 1995, 151:675-681.

  36. Murray RP, Johnston JJ, Dolce JJ, Lee WW, O'Hara P, for the Lung Health Study Research Group. Social support for smoking cessation and abstinence: The Lung Health Study. Addictive Behaviors 1995, 20(2):159-170.

  37. Pope CA, III and Kanner RE. Acute effects of PM 10 pollution on pulmonary function of smokers with mild to moderate chronic obstructive pulmonary disease. Am Rev Respir Dis 1993, 147:1336-1340.

  38. Utell MJ. Editorial: Particulate air pollution and health: New evidence on an old problem. Am Rev Respir Dis 1993, 147:1334-1335.

  39. Owens G. Editorial: Obstructive, occupational, and environmental diseases: editorial overview. Current Opinion in Pulmonary Medicine 1995, 1:73-75.

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  40. Istvan J, Murray R, Voelker H, for the Lung Health Study Research Group. The relationship between patterns of alcohol consumption and body weight. International J Epidemiology 1995, 24(3):543-546.

  41. Rand CS, Nides M, Cowles MK, Wise RA, Connett J, for the Lung Health Study Group. Long-term metered-dose inhaler adherence in a clinical trial.Am J Respir Crit Care Med 1995, 152:580-588.

  42. Murray RP, Istvan JA, Voelker HT, for the Lung Health Study Research Group. Does cessation of smoking cause a change in alcohol consumption? Evidence from the Lung Health Study. Substance Use & Misuse 1996, 31(2):141-156.

  43. Murray RP, Bailey WC, Daniels K, Bjornson WM, Kurnow K, Connett JE, Nides MA, Kiley JP, for the Lung Health Study Research Group. Safety of nicotine polacrilex gum used by 3,094 participants in the Lung Health Study. Chest 1996, 109:438-445.

  44. Cowles MK, Carlin BP, Connett JE. Bayesian tobit modeling of longitudinal ordinal clinical trial compliance data with nonignorable missingness.J Am Statistical Association 1996, 91(433):86-98.

  45. Simmons MS, Nides MA, Rand CS, Wise RA, Tashkin DP. Trends in Compliance with Bronchodilator Inhaler Use Between Follow up Visits in a Clinical Trial. Chest 1996, 109:963-968.

  46. Kanner RE for the Lung Health Study Research Group. Early intervention in chronic obstructive pulmonary disease: A review of the Lung Health Study results. Medical Clinics of North Am 1996, 80(3):523-547.

  47. Tashkin DP, Altose MD, Connett JE, Kanner RE, Lee WW, and Wise RA, for the Lung Health Study Research Group. Methacholine reactivity predicts changes in lung function over time in smokers with early chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1996, 153:1802-1811.

  48. Murray RP, Voelker HT, Rakos RF, Nides MA, McCutcheon VJ, Bjornson W. Intervention for relapse to smoking: The Lung Health Study restart programs. Addictive Behaviors 1997, 22(2):281-286.

  49. Bjornson W. Early chronic obstructive pulmonary disease: Results from the Lung Health Study. American Journal of Health Behavior 1996, 20(5):270-278.

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  50. Wise RA, Enright PL, Connett JE, Anthonisen NR, Kanner RE, Lindgren P, O'Hara P, Owens GR, Rand CS, Tashkin DP for the Lung Health Study Research Group. Effect of weight gain on pulmonary function after smoking cessation in the Lung Health Study. Am J Respir Crit Care Med, 1998, 157:866-872.

  51. Murray RP, Nides MA, Istvan JA, Daniels K. Levels of cotinine associated with long-term ad-libitum nicotine polacrilex use in a clinic trial. Addictive Behaviors 1998, 23(4):529-535.

  52. O'Hara P, Connett JE, Lee WW, Nides M, Murray R, Wise R. Early and late weight gain following smoking cessation in the Lung Health Study. Am J Epidemiol 1998, 148(9):821-830.

  53. Thun MJ and Colditz GA. Invited commentary on "Early and late weight gain following smoking cessation in the Lung Health Study". Am J Epidemiol 1998, 148(9):831-832.

  54. Murray RP, Istvan JA, Daniels K, Beaudoin CM. Alcohol and morbidity in the Lung Health Study. J Studies on alcohol 199, 59:250-257.

  55. Murray R, Anthonisen NR, Connet JE, Wise RA, Lindgren PG, Green PG and Nides MA, for the Lung Health Study Research Group. Effect of multiple attempts to quit smoking and relapses to smoking on pulmonary function. J Clin Epidemiol 1998, 51:1317-1326.

  56. Kanner RE, Connett JE, Williams DE, Buist AS for the Lung Health Study Research Group. Effects of Randomized Assignment to a Smoking Cessation Intervention and Changes in Smoking Habits on Respiraory Symptoms in Smokers with Early Chronic Obstructive Pulmonary Disease: The Lung Health Study. Am J Med 1999, 106:410-416.

  57. Istvan JA, Lee WW, Buist AS, and Connett JE. Relation of salivary cotinine to blood pressure in middle-aged cigarette smokers. Am Heart J 1999, 137:928-931.

  58. Scanlon PD, Connett JE, Waller LA, Altose MD, Bailey WC, Buist AS, and Tashkin DP, for the Lung Health Study Research Group. Smoking cessation and lung function in mild-to-moderate COPD: The Lung Health Study. Am J Respir Crit Care Med 2000, 161:381-390.

  59. Murray RP, Gerald LB, Lindgren PG, Connett JE, Rand CS, Anthonisen NR. Characteristics of participants who stop smoking and sustain abstinence for 1 and 5 years in the Lung Health Study. Prev Med 2000, 30:392-400.

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  60. Simmons MS, Nides MA, Rand CS, Wise RA, Taskin DP. Unpredictability of deception in compliance with physician-prescribed bronchodilator inhaler use in a clinical trial. Chest 2000, 118:290-295.

  61. The Lung Health Study Research Group [writing group: Wise R, Connett J, Weinmann, G, Scanlon P, Skeans M]. Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease. NEJM 2000, 343:1902-1909.

  62. Sandford AJ, Chagani T, Weir TD, Connett JE, Anthonisen NR, Pare PD. Susceptibility genes for rapid decline of lung function in the Lung Health Study. Am J Respir Crit Care Med 2001, 163:469-473.

  63. Kanner RE, Anthonisen NR, Connett JE for the Lung Health Study Research Group. Lower respiratory illnesses promote FEV1 decline in current smokers but not ex-smokers with mild COPD: Results from the Lung Health Study. Am J Respir Crit Care Med 2001, 164:358-364.

  64. Joos L, McIntyre L, Ruan J, Connet JE, Anthonisen NR, Weir TD, Pare PD, Sandford AJ. Association of IL-1B and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers. Thorax 2001, 56:863-866.

  65. Murray RP, Connett JE, Buist AS, Gerald LB, Eichenhorn MS. Experience of Black participants in the Lung Health Study smoking cessation intervention program. Nicotine & Tobacco Research 2001, 3:375-382.

  66. Joos L, He JQ, Shepherdson MB, Connett JE, Anthonisen NR, Pare PD, Sandford AJ. The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. Human Molecular Genetics 2002, 11:569-576.

  67. He J, Ruan J, Connett JE, Anthonisen NR, Pare PD, Sandford AJ. Antioxidant gene polymorphisms and susceptibility to a rapid decline in lung function in smokers. Am J Respir Cirt Care Med 2002 166:323-328.

  68. Anthonisen NR, Connett JE, Enright PL, Manfreda J and the Lung Health Study Research Group. Hospitalizations and mortality in the Lung Health Study. Am J Respir Crit Care Med 2002, 166:333-339.

  69. Anthonisen NR, Connett JE, Murray RP and The Lung Health Study Research Group. Smoking and lung function of Lung Health Study participants after 11 years. Am J Respir Crit Care Med 2002, 166:675-679.

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  70. Murray RP, Connett JE, Istvan JA, Nides MA, and Rempel-Rossum S. Relations of cotinine and carbon monoxide to self-reported smoking in a cohort of smokers and ex-smokers followed over five years. Nicotine and Tobacco Research 2002, 4:287-294.

  71. Murray RP, Connett JE, Rand CS, Pan W, Anthonisen NR. Persistence of the effect of the Lung Health Study (LHS) smoking intervention over eleven years. Prev Med 2002, 35:314-319.

  72. Enright PL, Connett JE, Bailey WC. The FEV1/FEV6 predicts lung function decline in adult smokers. Resp Med 2002, 96:444-449.

  73. He J, Connett JE, Anthonisen NR, Sandford AJ. Polymorphisms in the IL13, IL13RA1, and IL4RA genes and rate of decline in lung function in smokers. Am J Respir Cell Mol Biol 2003, 28:379-385.

  74. Response to Letter-to-the-Editor from Boehringer: Anthonisen NR, Manfreda J, Connett JE, Enright PL. Am J Respir Crit Care Med 2003, 167:801-802.

  75. Connett JE, Murray RP, Buist AS, Wise RA, Bailey WC, Lindgren PG, Owens GR, for the Lung Health Study Research Group. Changes in smokeing status affect women more than men: Results of the Lung Health Study. Am J Epidemiol 2003, 157:973-797.

  76. Eichenhorn MS, Wise RA, Madhok TC, Gerald LB, Bailey WC, Tashkin DP, Scanlon PD, and the Lung Health Study Research Group. Lack of long-term adverse adrenal effects from inhaled triamcinolone. CHEST 2003, 124:57-62.

  77. Joos L, Weir TD, Connett JE, Anthonisen NR, Wood R, Pare PD, Sandford AJ. Polymorphisms in the B2 adrenergic receptor and bronchodilator response, bronchial hyperresponseiveness, and rate of decline in lung function in smokers. Thorax 2003, 58:703-707.

  78. Wise RA, Kanner RE, Lindgren P, Connett JE, Altose MD, Enright PL, Tashkin DP, for the Lung Health Study Research Group. The effect of smoking intervention and an inhaled bronchodilator on airways reactivity in COPD: The Lung Health Study. CHEST 2003, 124:449-458.

  79. Kasuga I, Pare PD, Ruan J, Connett JE, Anthonisen NR, Sandford AJ. Lack of association of group specific component haplotypes with lung function in smokers. Thorax 2003, 58:790-793.

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  80. Hughes JR, Lindgren PG, Connett JE, Nides MA. Smoking reduction in the Lung Health Study. Nicotine & Tobacco Research 2004, 6(2):275-280.

  81. He J, Connett JE, Anthonisen NR, Pare PD, Sandford AJ. Glutathione S-transferase variants and their interaction with smoking on lung function. Am J Respir Crit Care Med 2004, 170:388-394.

  82. Scanlon P, Connett JE, Wise R, Tashkin D, Madhok T. Skeans M, Carpenter P, Bailey W, Buist AS, Eichenhorn M, Kanner R, Weinmann G, and the Lung Health Study Research Group. Loss of bone density with inhaled triamcinolone in Lung Health Study II. Am J Respir Crit Care Med 2004, 170:1302-1309.

  83. Tashkin DP, Murray HE, Skeans MA, Murray RP, for the Lung Health Study Research Group. Skin manifestations of inhaled corticosteroids in COPD patients: Results from Lung Health Study II. Chest 2004, 126:1123-1133.

  84. Anthonisen NR, Skeans MA, Wise RA, Manfreda J, Kanner RE, Connett JE for the Lung Health Study Research Group. The effects of a smoking cessation intervention on 14.5 year mortality: A randomized controlled trial. Ann Intern Med 2005, 142:233-239.

  85. Simmons MS, Connett JE, Nides MA, Lindgren PG, Kleerup EC, Murray RP, Bjornson WM and Tashkin DP. Smoking reduction and the rate of decline in FEV1: results from the Lung Health Study. Eur Respir J 2005, 25:1011-1017.

  86. Murray RP, Connett JE, Makela P, Rehm J. Difficulty in demonstrating a risk from drinking pattern in fourteen years of coronary heart disease morbidity and mortality: The Lung Health Study. Addictive Behaviors 2005, 30:875-887.

  87. Anthonisen NR, Lindgren PG, Tashkin DP, Kanner RE, Scanlon PD, Connett JE for the Lung Health Study Research Group. Bronchodilator response in the Lung Health Study over 11 years. Eur Respir J 2005, 26:45-51.

  88. Kasuga I, Ruan J, Connett JE, Anthonisen NR, Sandford AJ. Lack of association of Human Leukocyte Antigen-B7 with COPD and rate of decline in lung function. Respir Med 2005, 99(12):1528-1533.

  89. Harber P, Crawford L, Liu K, Schacter L. Working words: Real-life lexicon of North American workers. J Occup Environ Med 2005, 47(8):859-864.

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  90. He JQ, Burkett K, Connett JE, Anthonisen NR, Pare PD, Sandford AJ. Interferon gamma polymorphisms and their interaction with smoking are associated with lung function. Hum Genet 2006, DOI 10.1007/s00439-006-0143-z (electronic publication).

  91. Herpel LB, Kanner RE, Lee SM, Fessler HE, Sciurba FC, Connett JE, and Wise RA for the Lung Health Study Research Group and the National Emphysema Treatment Trial Research Group. Variability of spirometry in chronic obstructive pulmonary disease: results from two clinical trials. Am J Respir Crit Care Med 2006, 173:1106-1113.

  92. Wallace AM, He JQ, Burkett KM, Ruan J, Connett JE, Anthonisen NR, Pare PD, and Sandford AJ. Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study. Respiratory Research (BioMed Central) 2006, 7:76 (15 May 2006).

  93. Man SFP, Connett JE, Anthonisen NR, Wise RA, Tashkin DP, Sin DD. C-Reactive protein and mortality in mild to moderate chronic obstructive pulmonary disease. Thorax 2006, 61:849-853.

  94. Ogawa E, Ruan J, Connett JE, Anthonisen NR, Pare PD, Sandford AJ. Transforming growth factor-B1 polymorphisms, airway responsiveness and lung function decline in smokers. Respir Med 2007, 101:938-943.

  95. Tanaka G, Sandford AJ, Burkett K, Connett JE, Anthonisen NR, Pare PD, He JQ. Tumour necrosis factor and lymphotoxin A polymorphisms and lung function in smokers. Eur Respir J 2007, 29:34-41.

  96. Harber P, Crawford L, Cheema A, Schacter L. Computer algorithm for automated work group classification from free text: the DREAM technique. J Occup Environ Med 2007, 49(1):41-49.

  97. Zhang X, Mahmudi-Azer S, Connett JE, Anthonisen NR, He JQ, Pare PD, Sandford AJ. Association of Hck genetic polymorphisms with gene expression and COPD. Hum Genet 2007, 120:681-690.

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If you have questions or comments on the Lung Health Study, please e-mail (by clicking on his name) Dr. John Connett (john-c@ccbr.umn.edu).

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Last modified: June 21, 2007