Title: Introduction to Bayesian Methods and Software for Data Analysis Instructors: Brad Carlin, University of Minnesota Laura Hatfield, Harvard Medical School Course description: Hierarchical Bayes methods enable the combining of information from similar and independent experiments, yielding improved inference for both individual and shared model characteristics. As a result of recent advances in computing and the consequent ability to evaluate complex models, Bayesian methods have increased in popularity in data analysis. This course introduces hierarchical Bayes methods, demonstrates their usefulness in challenging applied settings, and shows how they can be implemented using modern Markov chain Monte Carlo (MCMC) computational methods. Related issues in Bayesian robustness, model assessment, and model selection and averaging are also discussed, including Bayes factors, predictive approaches, and penalized likelihood methods including DIC. We also provide an introduction to and live demonstration of WinBUGS, the most general and widely-used Bayesian software package available to date. Use of the methods will be demonstrated in advanced high-dimensional model settings (e.g., nonlinear longitudinal modeling or clinical trial design and analysis), where the MCMC Bayesian approach often provides the only feasible alternative that incorporates all relevant model features. Target Audience: Practicing statisticians and biostatisticians seeking to learn new methods for analyzing complex datasets drawn from industry, agriculture, biomedical science, public health, and other fields; Statistical consultants looking to broaden their toolkit of procedures for challenging datasets; Educators wanting to incorporate recent developments in Bayesian methods into their courses on nonlinear models, longitudinal data analysis, time series, survival analysis, spatial statistics, and so on; Statistical researchers in application areas who need an introduction to the benefit of Bayesian methods for hierarchical modeling; Masters and Ph.D. students in statistics, biostatistics, epidemiology, and related fields who recognize the need for advanced modeling tools in their thesis research, but whose departments do not offer formal course work on Bayesian methods and software. Requirements for participation (e.g., any specific prior knowledge): Short course participants should have an M.S. (or advanced undergraduate) understanding of mathematical statistics at, say, the Hogg and Craig (1978) level. Basic familiarity with common statistical models (e.g., the linear regression model) and computing will be assumed, but we will not assume any significant previous exposure to Bayesian methods or Bayesian computing. The course is generally aimed at students and practicing statisticians who are intrigued by all the fuss about Bayes and Gibbs, but who may still mistrust the approach as theoretically mysterious and practically cumbersome. Also, students are invited to bring their own laptop computers to the session, and to have the latest versions of WinBUGS and R already installed on these computers. Both of these programs are freely available from http://www.mrc-bsu.cam.ac.uk/bugs/winbugs/contents.shtml and http://www.r-project.org/ respectively.