Example 3. Change in Clinical and Laboratory Values at 12-Months by Group in TOMHS
Acebutolol
Amlodipine
Chlorthalidone
Doxazosin
Enalapril
Placebo
Clinical
Mean
SE
Mean
SE
Mean
SE
Mean
SE
Mean
SE
Mean
SE
P (5df)
Δ Diastolic BP (mmHg)
-13.7
0.7
-12.9
0.7
-13.1
0.7
-12.0
0.7
-12.2
0.7
-8.1
0.5
<.001
Δ Systolic BP (mmHg)
-20.1
1.4
-17.5
1.1
-21.8
1.3
-16.1
1.2
-17.6
1.2
-10.6
1.0
<.001
Δ Pulse (b/min)
-8.7
0.9
-0.8
0.9
-1.9
0.8
-0.9
1.0
-2.5
0.8
-2.3
0.7
<.001
Δ Weight (lb)
-9.9
0.7
-11.1
0.9
-12.4
0.9
-8.6
0.8
-11.7
0.8
-9.9
0.7
0.014
Laboratory
Δ Total Cholesterol (mg/dl)
-12.7
2.3
-7.2
2.6
1.0
2.3
-12.7
2.3
-8.0
2.1
-5.2
1.6
<.001
Δ HDL Cholesterol (mg/dl)
-0.4
0.6
2.4
0.6
2.3
0.7
2.3
0.6
2.6
0.5
1.6
0.4
0.003
Δ Glucose (mg/dl)
-2.0
1.3
-1.7
1.0
-1.1
0.9
-1.1
1.5
-3.8
1.0
-3.2
0.9
0.421
Δ Potassium (mg/dl)
0.0
0.0
-0.0
0.0
-0.4
0.0
0.0
0.0
0.1
0.0
-0.0
0.0
<.001
Number of Participants
126
121
124
129
127
221
Notes: P-values based on GLM
pn=example3 rundate=31AUG2018