Statistical Genetics (PubH 8400 Spring 2007 Part I)

Outline (8 weeks)

  1. Introduction; meiosis indicator, identity by descent and identity coefficients, likelihood caculation on pedigrees.
  2. Linkage analysis, LOD score, Elston-Stewart and Lander-Green algorithms, MCMC methods, nonparametric linkage.
  3. Quantitative traits, variance component linkage methods.
  4. Modern population genetics, coalescent theory and its applications.
  5. Population based association studies, linkage disequilibrium (LD), haplotype, population admixture.
  6. Family based association, TDT methods, design of family based studies.

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