Course Description
Genetic mapping of complex traits in humans, modern population genetics with an emphasis on inference based on observed molecular genetics data, association studies; statistical methods for low- and high-level analysis of genomic and proteomic data including topics on multiple comparison and gene network modeling. Note this course is a continuation of PubH 7445 for PhD students in Biostatistics or Statistics.
Course Prerequisites
- PubH 7445 Statistics for Human Genetics and Molecular Biology
- Statistical theory at the level of Stat 5101-2.
- A college-level molecular genetics course is recommended.
- Or permission by instructors.
Course Goals
After taking the course, the students are expected to understand the statistical challenges in genetics and genomics and important statistical methods developed for this field. The students should then be able conduct independent reading and research in the future.
Course Text and Readings
No required text books.
Evaluation and Grading
Course grade is based on bi-weekly homework (70%) and a final project (30%). A letter grade will be determined from the percentage of points each student receives. The curve for final grades will be: A = 95-100; A- = 90-94; B+ = 85-89; B = 80-84; B- = 75-79; C+ = 70-74; C = 65-69; C- = 60-64; F = below 60. For those registered S/N, S = 60-100.
Homework assignments will be due at the start of the class. Unless arrangements have been made with the instructor PRIOR to the due date, homework turned in after it is due will have 50% points deducted and no credit will be given after the next homework is due.
Incomplete Grade
A grade of incomplete "I" shall be assigned at the discretion of the instructor when, due to extraordinary circumstances, the student was prevented from completing the work of the course on time. The assignment of an incomplete requires a written agreement between the instructor and student specifying the time and manner in which the student will complete the course requirements. In no event may any such written agreement allow a period of longer than one year to complete the course requirements. University of Minnesota Uniform Grading and Transcript Policy. A link to the policy can be found at http://onestop.umn.edu.
University of Minnesota Uniform Grading and Transcript Policy
A link to the policy can be found at onestop.umn.edu.
Other Course Information and Policies
Grade Option Change (if applicable)
For full-semester courses, students may change their grad option, if applicable, through the second week of the semester. Grade option change deadlines for other terms (i.e. summer and half-semester) can be found at onestop.umn.edu.
Course Withdrawal
Students should refer to the Refund and Drop/Add Deadlines for the particular term at onestop.umn.edu for information and deadlines for withdrawing from a course. As a courtesy, students should notify their instructor and, if applicable, advisor of their intent to withdraw.
Students wishing to withdraw from a course after the noted final deadline for a particular term must contact the School of Public Health Student Services Center at sph-ssc@umn.edu for further information
Student Conduct, Scholastic Dishonesty and Sexual Harassment Policies
Students are responsible for knowing the University of Minnesota, Board of Regents' policy on Student Conduct and Sexual Harassment found at http://www.umn.edu/regents/polindex.html.
Students are responsible for maintaining scholastic honesty in their work at all times. Students engaged in scholastic dishonesty will be penalized, and offenses will be reported to the Office of Student Academic Integrity (OSAI, http://www.osai.umn.edu).
The University's Student Conduct Code defines scholastic dishonesty as "plagiarizing; cheating on assignments or examinations; engaging in unauthorized collaboration on academic work; taking, acquiring, or using test materials without faculty permission; submitting false or incomplete records of academic achievement; acting alone or in cooperation with another to falsify records or to obtain dishonestly grades, honors, awards, or professional endorsement; or altering, forging, or misusing a University academic record; or fabricating or falsifying of data, research procedures, or data analysis."
Plagiarism is an important element of this policy. It is defined as the presentation of another's writing or ideas as your own. Serious, intentional plagiarism will result in a grade of "F" or "N" for the entire course. For more information on this policy and for a helpful discussion of preventing plagiarism, please consult University policies and procedures regarding academic integrity:
Students are urged to be careful that they properly attribute and cite others' work in their own writing. For guidelines for correctly citing sources, go to http://tutorial.lib.umn.edu/ and click on "Citing Sources".
In addition, original work is expected in this course. It is unacceptable to hand in assignments for this course for which you receive credit in another course unless by prior agreement with the instructor. Building on a line of work begun in another course or leading to a thesis, dissertation, or final project is acceptable.
If you have any questions, consult the instructor.
Disability Statement
It is University policy to provide, on a flexible and individualized basis, reasonable accommodations to students who have a documented disability (e.g., physical, learning, psychiatric, vision, hearing, or systemic) that may affect their ability to participate in course activities or to meet course requirements. Students with disabilities are encouraged to contact Disability Services to have a confidential discussion of their individual needs for accommodations. Disability Services is located in Suite180 McNamara Alumni Center, 200 Oak Street. Staff can be reached by calling 612/626-1333 (voice or TTY).