Course Objective

The course will provide details on the construction and application of different mathematical and stochastic models in genetic studies. We will learn about segregation analysis, multipoint linkage, population-based and family-based association analysis. Different aspects of population genetics such as testing Hardy-Weinberg equilibrium, likelihood estimation of allele frequencies, population structure, linkage disequilibrium, and haplotyping will also be discussed. Students will learn both the theory and application of statistical genetics and gain hands-on experience with analyzing genetic data using available R packages or other analysis softwares. This is a 3 credit course. Prequisites are Stat 8101-2 or equivalent; PubH8432; or instructor's consent. Some experience with Splus or R is useful; background in Molecular Biology is desirable.