Wei Pan

Other affiliations at the U of M:

• Faculty, Graduate Program in Bioinformatics
• Member, Biomedical Genomics Center
• Member, Cancer Center

Education:

• PhD in Statistics, UW-Madison, 1997.
• MS in Computer Science, UW-Madison, 1996.
• BEng in Computer Engineering & BS in Applied Math, Tsinghua U, Beijing, 1989.

Teaching:

• Spring 2026: PubH 8475/Stat 8056. Advanced Topics in Machine Learning.
• Spring 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2024: PubH (7475/)8475/Stat 8056. Statistical Learning and Data Mining.
• Fall 2006-2013: PubH 7450. Survival Analysis.
• Spring 2007: PubH 7475/8400. Statistical Learning and Data Mining.
• Spring 2006: BINF 5480. Bioinformatics Journal Club.
• Spring 2006: PubH 7407. Categorical Data Analysis.
• Spring 2003: PubH 5470-2 Statistics in Genetics and Molecular Biology. Part III (Microarray Data Analysis)

Research Interests:

• Statistical genetics, especially genetic association testing for GWAS and sequencing data.
• Bioinformatics: integrative analysis of multiple types of omics data; analysis of microarray gene expression data. (What is bioinformatics? Bioinformatics at U of M.)
• Statistical/machine learning/AI: learning from multi-modal data; supervised learning (classification), unsupervised learning (clustering), and semi-supervised learning; penalized/regularized methods.
• Survival analysis and clinical trials: estimation with truncated and/or (interval) censored data.
• Generalized linear models with correlated responses: GEE, mixed effects models.

Some recent publications:

• Malakhov MM, Pan W. Co-expression-wide association studies link genetically regulated interactions with complex traits. Nat Commun. 2025 Dec 11;16(1):11061. doi: 10.1038/s41467-025-66039-6. PMID: 41381446; PMCID: PMC12698763. Link
• He R, Ren J, Malakhov MM, Pan W. Enhancing nonlinear transcriptome- and proteome-wide association studies via trait imputation with applications to Alzheimer's disease. PLoS Genet. 2025 Apr 10;21(4):e1011659. doi: 10.1371/journal.pgen.1011659. PMID: 40209152; PMCID: PMC12040266. Link
• Fang L, Xue H, Lin Z, Pan W. Multivariate proteome-wide association study to identify causal proteins for Alzheimer disease. Am J Hum Genet. 2025 Feb 6;112(2):291-300. doi: 10.1016/j.ajhg.2024.12.010. Epub 2025 Jan 9. PMID: 39793580; PMCID: PMC11866954. Link
• Yao Y, Zhang MJ, Wang W, Zhuang Z, He R, Ji Y, Knutson KA, Norby FL, Alonso A, Soliman EZ, Tang W, Pankow JS, Pan W, Chen LY. Multimodal data integration to predict atrial fibrillation. Eur Heart J Digit Health. 2024 Nov 4;6(1):126-136. doi: 10.1093/ehjdh/ztae081. PMID: 39846068; PMCID: PMC11750194. Link
• Wang M, Shen X, Pan W. Causal Discovery with Generalized Linear Models through Peeling Algorithms. J Mach Learn Res. 2024;25:310. PMID: 39758585; PMCID: PMC11699566. Link
• Lin Z, Pan I, Pan W. On network deconvolution for undirected graphs. Biometrics. 2024 Oct 3;80(4):ujae112. doi: 10.1093/biomtc/ujae112. PMID: 39377517; PMCID: PMC11459367. Link
• Ramprasad P, Pai N, Pan W. Enhancing personalized gene expression prediction from DNA sequences using genomic foundation models. HGG Adv. 2024 Oct 10;5(4):100347. doi: 10.1016/j.xhgg.2024.100347. Epub 2024 Aug 27. PMID: 39205391; PMCID: PMC11416237. Link
• Lin Z, Pan W. A robust cis-Mendelian randomization method with application to drug target discovery. Nat Commun. 2024 Jul 18;15(1):6072. doi: 10.1038/s41467-024-50385-y. PMID: 39025905; PMCID: PMC11258283. Link
• Wang P, Lin Z, Xue H, Pan W. Collider bias correction for multiple covariates in GWAS using robust multivariable Mendelian randomization. PLoS Genet. 2024 Apr 22;20(4):e1011246. doi: 10.1371/journal.pgen.1011246. PMID: 38648211; PMCID: PMC11065275. Link
• Malakhov MM, Dai B, Shen XT, Pan W. A bootstrap model comparison test for identifying genes with context-specific patterns of genetic regulation. Ann Appl Stat. 2024 Sep;18(3):1840-1857. doi: 10.1214/23-aoas1859. Epub 2024 Aug 5. PMID: 39421855; PMCID: PMC11484521. Link
• Ren J, Pan W. Statistical inference with large-scale trait imputation. Stat Med. 2024 Feb 20;43(4):625-641. doi: 10.1002/sim.9975. Epub 2023 Dec 1. PMID: 38038193; PMCID: PMC10848238. Link
• Chen L, Li C, Shen X, Pan W. Discovery and inference of a causal network with hidden confounding. J Am Stat Assoc. 2024;119(548):2572-2584. doi: 10.1080/01621459.2023.2261658. Epub 2023 Nov 17. PMID: 39980628; PMCID: PMC11841811. Link
• Li C, Shen X, Pan W. Nonlinear causal discovery with confounders. J Am Stat Assoc. 2024;119(546):1205-1214. doi: 10.1080/01621459.2023.2179490. Epub 2023 Mar 15. PMID: 39077372; PMCID: PMC11286219. Link

Other research related:

• Programs : Some computer programs used in my papers.
• My Google Scholar Citations.
• Searching PubMed. (But many "Pan W"'s are NOT me!)

Recent talks:

• CCBR, U of Minnesota slides.
• A novel and efficient algorithm for de novo discovery of mutated driver pathways in cancer Computer Science, U of Minnesota slides.
• Two-sample testing with high-dimensional genetic and neuroimaging data, UCI, UT Southwestern Medical Center, slides, UC-Irvine, UT Southwestern Medical Center, U Georgia, 2016.
• Testing for group differences in brain functional connectivity, Banff, Feb 4, 2016.
• Testing for Genetic Association with Multiple Neuroimaging Traits Imaging Genetics WG, Oct 3, 2014.
• A powerful and adaptive association test for rare variants. UNC, Sept 2014. JSM 2014, Boston, August 2014. UW-Seattle, April 2014. UT-Houston, March 2014.
• Discussion, ENAR Meeting, Baltimore, MD, March 19, 2014.
• A New Framework for Clustering Analysis. The Ninth ICSA International Conference, Hong Kong, Dec 2013; Australian Statistical Conference/IMS Annual Meeting 2014, Sydney, July 2014.
• Adjusting for Population Stratification with Principal Components and Sequencing Data. JSM 2013, Montreal, Canada, August 2013. U Iowa Biostat Seminar, Sept 2013. Michigan State U Stat Seminar, Oct 2013.
• An introduction to statistical tests in GWAS, SIBS, UofM, July 25, 2013; July 22, 2015.
• Network-based penalized regression, departmental seminars at Duke, PSU, UW-Madison, NYU, UPenn, 2012-2013.
• IBC, August 27, 2012.
• Statistics seminar, Purdue U, Oct 28, 2011.
• IHI seminar, U of M, MN, Oct 6 2011.
• Renmin U, Biostatistics Symposium, Beijing, China, July 18, 2010.
• UM Biostatistics seminar, Minneapolis, MN, Dec 3 2008.
• UM Biostatistics seminar, Minneapolis, MN, Dec 5 2007. SH.
• CAMDA 2007 keynote, Valencia, Spain, Dec 13 2007.
• PSB 2008 talk, Big Island, Hawaii, Jan 7, 2008.

Seminars at U of M:

• Biostatistics Seminar
• Statistics Genetics and Genomics Seminar
• Bioinformatics Seminar
• Health Informatics Seminar
• Statistics Seminar

Professional Activities:

• ENAR (IBS), member
• IMS, Fellow (2020-- )
• ASA, Fellow (2010-- )
• ICSA
• Statistics in Medicine, Editorial Board, Aug 2002--2006
• JASA, Associate Editor, Oct 2003--2006
• Referee for Applied Statistics, Biometrics, Biometrical J, Biostatistics, Comm. in Statist., Comp. Statist. and Data Analysis, JASA, JCGS, JRSS-B, Lifetime Data Analysis, Scandinavian Journal of Statistics, Statistics in Medicine, Technometrics and American Journal of Epidemiology, American Journal of Public Health, BMC Bioinformatics, Bioinformatics, Nucleic Acids Res, Nature, Pharmacogenomics.

Journals:

• Statistics and bioinformatics journals related to my research interests
• Medical journals
• Pattern Recognition journals